Open AccessSensitivity and Specificity of Immunocytochemical Staining of Mycobacterial Antigens in the Cytoplasm of Cerebrospinal Fluid Macrophages for Diagnosing Tuberculous Meningitis
Author(s) -
Yuquan Shao,
Ping Xia,
Tao Zhu,
Jiong Zhou,
Yuan Yuan,
Hao Zhang,
Jianjun Chen,
Xingyue Hu
Publication year - 2011
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01323-11
Subject(s) - cerebrospinal fluid , tuberculous meningitis , staining , meningitis , pathology , antigen , immunocytochemistry , biology , cytoplasm , tuberculosis , immunology , medicine , microbiology and biotechnology , biochemistry , psychiatry
The sensitivity and specificity of immunocytochemical staining of mycobacterial antigens in the cytoplasm of cerebrospinal fluid (CSF) macrophages for diagnosis of tuberculous meningitis (TBM) was prospectively compared with Ahuja criteria from 393 consecutive CSF specimens. The assay can play an important role for the diagnosis of TBM, with sensitivity of 73.5% and specificity of 90.7%.
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