Specimen Dilution Improves Sensitivity of the Amplified Mycobacterium tuberculosis Direct Test for Smear Microscopy-Positive Respiratory Specimens | Zendy

Renata Leborato Guerra | Zendy; James F. Baker | Zendy; Roya Alborz | Zendy; Derek T. Armstrong | Zendy; Julia A. Kiehlbauch | Zendy; Marcus Barreto Conde | Zendy; Susan E. Dorman | Zendy; Nancy Hooper | Zendy

Open Access

Specimen Dilution Improves Sensitivity of the Amplified Mycobacterium tuberculosis Direct Test for Smear Microscopy-Positive Respiratory Specimens

Author(s) -

Renata Leborato Guerra,

James F. Baker,

Roya Alborz,

Derek T. Armstrong,

Julia A. Kiehlbauch,

Marcus Barreto Conde,

Susan E. Dorman,

Nancy Hooper

Publication year - 2007

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01313-07

Subject(s) - mycobacterium tuberculosis , tuberculosis , medicine , microbiology and biotechnology , dilution , microscopy , respiratory system , pathology , biology , physics , thermodynamics

Specimen dilution has been proposed as a strategy to minimize amplifiedMycobacterium tuberculosis direct (MTD) test inhibition (N. Pollock, J. Westerling, and A. Sloutsky, Am. J. Clin. Pathol. 126:142-147, 2006; A. Sloutsky, L. L. Han, and B. G. Werner, J. Clin. Microbiol. 42:1547-1551, 2004). We evaluated the impact of respiratory specimen dilution on MTD test accuracy in a public health laboratory. The difference in MTD test sensitivity between the dilution and conventional methods was 15.9% (P = 0.001) for smear microscopy-positive specimens and −3.6% (P = 0.38) for smear microscopy-negative specimens.

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