Open AccessXpert MTB/RIF for Rapid Diagnosis of Tuberculous Lymphadenitis from Fine-Needle-Aspiration Biopsy Specimens
Author(s) -
Louis J. Ligthelm,
Mark P. Nicol,
Kim G.P. Hoek,
Rachael K. Jacobson,
Paul D. van Helden,
Ben J. Marais,
Robin M. Warren,
Colleen A. Wright
Publication year - 2011
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01310-11
Subject(s) - medicine , tuberculous lymphadenitis , biopsy , tuberculosis , cytology , fine needle aspiration , confidence interval , false negative reactions , mycobacterium tuberculosis , diagnostic accuracy , pathology , radiology , gastroenterology
This study demonstrates the excellent diagnostic accuracy of the Xpert MTB/RIF test in patients with tuberculous lymphadenitis. The test sensitivity and specificity were 96.7% (95% confidence interval [CI], 86.6 to 100%) and 88.9% (95% CI, 69.6 to 100%), respectively, and it correctly identified 6/6 (100%) of the cytology smear-negative/culture-positive cases and 1 of 2 (50%) rifampin-resistant cases.
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