Open AccessAsymptomatic Leprosy Infection among Blood Donors May Predict Disease Development and Suggests a Potential Mode of Transmission
Author(s) -
Isabela Maria Bernardes Goulart,
Sérgio Araújo,
Adilson Botelho Filho,
Paulo Henrique Ribeiro de Paiva,
Luíz Ricardo Goulart
Publication year - 2015
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01305-15
Subject(s) - leprosy , asymptomatic , mycobacterium leprae , immunology , transmission (telecommunications) , antibody , medicine , blood transfusion , disease , biology , virology , electrical engineering , engineering
Blood donor samples (1,007) were assessed for anti-phenolic glycolipid 1 (PGL-1) IgM antibodies andMycobacterium leprae DNA presence, which had 3.8% and 0.3% positivity, respectively. After a 5-year follow-up period, six individuals with positive markers developed leprosy, raising the hypothesis that asymptomatic infection among blood donors may be an undisclosed mode of leprosy transmission via transfusion.
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