Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing | Zendy

Radha Rajasingham | Zendy; Rachel Wake | Zendy; Tafese Beyene | Zendy; Andrew Katende | Zendy; Emílio Letang | Zendy; David R. Boulware | Zendy

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Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing

Author(s) -

Radha Rajasingham,

Rachel Wake,

Tafese Beyene,

Andrew Katende,

Emílio Letang,

David R. Boulware

Publication year - 2018

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01238-18

Subject(s) - meningitis , fulminant , medicine , viral meningitis , cryptococcal meningitis , immunology , human immunodeficiency virus (hiv) , intensive care medicine , cerebrospinal fluid , virology , pediatrics , viral disease , bacterial meningitis

Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg), with the recent development and distribution of a point-of-care lateral flow assay. This assay is highly sensitive and specific in cerebrospinal fluid (CSF), but is also sensitive in the blood to detect CrAg prior to meningitis symptoms.

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