Single-Nucleotide Polymorphisms in Rv2629 Are Specific for Mycobacterium tuberculosis Genotypes Beijing and Ghana but Not Associated with Rifampin Resistance | Zendy

Susanne Homolka | Zendy; Claudio U. Köser | Zendy; John Archer | Zendy; Sabine Rüsch–Gerdes | Zendy; Stefan Niemann | Zendy

Open Access

Single-Nucleotide Polymorphisms in Rv2629 Are Specific for Mycobacterium tuberculosis Genotypes Beijing and Ghana but Not Associated with Rifampin Resistance

Author(s) -

Susanne Homolka,

Claudio U. Köser,

John Archer,

Sabine Rüsch–Gerdes,

Stefan Niemann

Publication year - 2008

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01237-08

Subject(s) - mycobacterium tuberculosis , genotype , biology , tuberculosis , single nucleotide polymorphism , virology , microbiology and biotechnology , beijing , genetics , medicine , gene , geography , pathology , archaeology , china

Sequence analysis of 58 multidrug-resistantMycobacterium tuberculosis complex strains from Germany and 55 susceptible strains from a reference collection comprising major phylogenetic lineages confirmed that variations in Rv2629, 191A/C and 965C/T, are specific for genotypes Beijing and Ghana, respectively, but not involved in the development of rifampin (rifampicin) resistance.

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