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Microevolution of Burkholderia pseudomallei during an Acute Infection
Author(s) -
Direk Limmathurotsakul,
Matthew T. G. Holden,
Paul Coupland,
Erin P. Price,
Narisara Chantratita,
Vanaporn Wuthiekanun,
Premjit Amornchai,
Julian Parkhill,
Sharon J. Peacock
Publication year - 2014
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01219-14
Subject(s) - burkholderia pseudomallei , melioidosis , biology , microevolution , burkholderia , microbiology and biotechnology , genotype , virology , bacteria , medicine , genetics , gene , environmental health , population
We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.

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