Open AccessMolecular Characteristics of the Mycobacterium tuberculosis LAM-RUS Family Prevalent in Central Russia
Author(s) -
Svetlana Dubiley,
Eugene Kirillov,
A. N. Ignatova,
В. Н. Степаншина,
I. G. Shemyakin
Publication year - 2007
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01217-07
Subject(s) - mycobacterium tuberculosis , biology , tuberculosis , gene , genetics , virology , genotype , most recent common ancestor , microbiology and biotechnology , phylogenetic tree , medicine , pathology
We analyzed IS6110 -associated polymorphisms in the phospholipase C genes of 107 isolates ofMycobacterium tuberculosis selected to be representative of isolates circulating in central Russia. We found that the majority of Latin American-Mediterranean family strains contained an insertion in a unique position in theplcA gene, suggesting a common ancestor. This insertion can serve as a specific genetic marker for this group, which we designate the LAM-RUS family.