Molecular Characteristics of the Mycobacterium tuberculosis LAM-RUS Family Prevalent in Central Russia | Zendy

Svetlana Dubiley | Zendy; Eugene Kirillov | Zendy; А. М. Игнатова | Zendy; V. N. Stepanshina | Zendy; I. G. Shemyakin | Zendy

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Molecular Characteristics of the Mycobacterium tuberculosis LAM-RUS Family Prevalent in Central Russia

Author(s) -

Svetlana Dubiley,

Eugene Kirillov,

А. М. Игнатова,

V. N. Stepanshina,

I. G. Shemyakin

Publication year - 2007

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01217-07

Subject(s) - mycobacterium tuberculosis , biology , tuberculosis , gene , genetics , virology , genotype , most recent common ancestor , microbiology and biotechnology , phylogenetic tree , medicine , pathology

We analyzed IS6110 -associated polymorphisms in the phospholipase C genes of 107 isolates ofMycobacterium tuberculosis selected to be representative of isolates circulating in central Russia. We found that the majority of Latin American-Mediterranean family strains contained an insertion in a unique position in theplcA gene, suggesting a common ancestor. This insertion can serve as a specific genetic marker for this group, which we designate the LAM-RUS family.

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