Open AccessIn Vivo Emergence of High-Level Macrolide Resistance in Streptococcus pneumoniae following a Single Dose of Azithromycin
Author(s) -
Heidi SmithVaughan,
Robyn L. Marsh,
Peter S Morris,
Amanda Leach
Publication year - 2007
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01213-07
Subject(s) - streptococcus pneumoniae , efflux , azithromycin , microbiology and biotechnology , gene , biology , in vivo , genetics , antibiotics
Resistance to macrolides in the pneumococcus is generally by virtue of an efflux pump (encoded by the mefA or mefE gene) or the presence of a ribosomal methylase (encoded by the ermB or, rarely, the ermA gene). Horizontal spread of these genes can occur through inter- and intraspecies recombination
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