Open AccessComparative Study of Nasopharyngeal Aspirate and Nasal Swab Specimens for Diagnosis of Acute Viral Respiratory Infection
Author(s) -
Rita Yn Tz Sung,
Paul K.S. Chan,
Kai Chow Choi,
Albert T. Yeung,
Albert M. Li,
Julian W. Tang,
Margaret Ip,
Tracy Tsen,
E. Anthony S. Nelson
Publication year - 2008
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01209-08
Subject(s) - virology , virus , respiratory system , viral culture , multiplex , immunofluorescence , respiratory infection , paramyxoviridae , medicine , multiplex polymerase chain reaction , biology , viral disease , polymerase chain reaction , immunology , antibody , bioinformatics , biochemistry , gene
Paired nasopharyngeal aspirate (NPA) and nasal swab (NS) samples from 475 children hospitalized for acute respiratory infection were studied for the detection of influenza virus, parainfluenza virus, respiratory syncytial virus, and adenovirus by immunofluorescence test, viral culture, and multiplex PCR assay. The overall sensitivity of viral detection with NPA specimens was higher than that obtained with NS specimens.