Diagnosis of Human Immunodeficiency Virus Type 1 Infection in Infants by Use of Dried Blood Spots and an Ultrasensitive p24 Antigen Assay | Zendy

Ada Cachafeiro | Zendy; Gayle Sherman | Zendy; Annette H. Sohn | Zendy; Consuelo M. BeckSagué | Zendy; Susan A. Fiscus | Zendy

Open Access

Diagnosis of Human Immunodeficiency Virus Type 1 Infection in Infants by Use of Dried Blood Spots and an Ultrasensitive p24 Antigen Assay

Author(s) -

Ada Cachafeiro,

Gayle Sherman,

Annette H. Sohn,

Consuelo M. BeckSagué,

Susan A. Fiscus

Publication year - 2008

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01181-08

Subject(s) - dried blood , virology , spots , human immunodeficiency virus (hiv) , antigen , virus , viral disease , medicine , immunology , biology , pathology , chemistry , chromatography

We tested 617 dried blood spots (DBS) from human immunodeficiency virus-exposed infants from five countries using an ultrasensitive p24 antigen assay (Up24). The sensitivity was 94.4% (67/71) and the specificity was 100% (431/431) for infants with DBS specimens ≤20 months old; DBS older than 30 months demonstrated only 72.2% sensitivity (39/54) (P < 0.001) but displayed 100% specificity (61/61).

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