Rapid Identification of OXA-48 and OXA-163 Subfamilies in Carbapenem-Resistant Gram-Negative Bacilli with a Novel Immunochromatographic Lateral Flow Assay | Zendy

Fernando Pasterán | Zendy; Laurence Denorme | Zendy; Isabelle Ote | Zendy; Sonia Gómez | Zendy; Denise De Belder | Zendy; Y. Glupczynski | Zendy; Pierre Bogaerts | Zendy; Bárbara Ghiglione | Zendy; P.P. Power | Zendy; Pascal Mertens | Zendy; Alejandra Corso | Zendy

Open Access

Rapid Identification of OXA-48 and OXA-163 Subfamilies in Carbapenem-Resistant Gram-Negative Bacilli with a Novel Immunochromatographic Lateral Flow Assay

Author(s) -

Fernando Pasterán,

Laurence Denorme,

Isabelle Ote,

Sonia Gómez,

Denise De Belder,

Y. Glupczynski,

Pierre Bogaerts,

Bárbara Ghiglione,

P.P. Power,

Pascal Mertens,

Alejandra Corso

Publication year - 2016

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01175-16

Subject(s) - bacilli , microbiology and biotechnology , gram , identification (biology) , biology , gram negative bacteria , gram negative bacterial infections , carbapenem , bacteria , antibiotics , escherichia coli , genetics , gene , botany

We assessed a novel immunochromatographic lateral flow assay for direct identification of OXA-48-like carbapenemases and accurate differentiation of allele variants with distinct substrate profiles (OXA-48 or OXA-163 subfamilies). The assay allowed rapid (less than 4 min) and reliable direct confirmation of OXA-163- and/or OXA-48-like enzymes (with 100% sensitivity and 100% specificity) from cultured colonies that were recovered from both solid medium and spiked blood culture bottles.

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