Ciprofloxacin-Resistant Salmonella enterica Serovar Typhi from Kuwait with Novel Mutations in gyrA and parC Genes | Zendy

Tzonyo Dimitrov | Zendy; Ali A. Dashti | Zendy; Ossama Albaksami | Zendy; Edet E. Udo | Zendy; Mehrez M. Jadaon | Zendy; M. John Albert | Zendy

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Ciprofloxacin-Resistant Salmonella enterica Serovar Typhi from Kuwait with Novel Mutations in gyrA and parC Genes

Author(s) -

Tzonyo Dimitrov,

Ali A. Dashti,

Ossama Albaksami,

Edet E. Udo,

Mehrez M. Jadaon,

M. John Albert

Publication year - 2008

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01161-08

Subject(s) - ciprofloxacin , serotype , salmonella enterica , microbiology and biotechnology , salmonella typhi , biology , salmonella , enterobacteriaceae , quinolone , antibacterial agent , virology , gene , bacteria , genetics , antibiotics , escherichia coli

Blood isolates ofSalmonella enterica serovar Typhi from two recently returned Bangladeshi patients in Kuwait were ciprofloxacin resistant, with ciprofloxacin MICs of 12 mg/liter for both isolates. Both isolates had three novelgyrA mutations (55-Leu→Trp, 87-Asp→Ala, and 106-Gln→Arg) and three novelparC mutations (84-Glu→Lys, 106-Trp→Gly, and 128-Tyr→Asp).

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