Open AccessCiprofloxacin-Resistant Salmonella enterica Serovar Typhi from Kuwait with Novel Mutations in gyrA and parC Genes
Author(s) -
T Dimitrov,
Ali A. Dashti,
Ossama Albaksami,
Edet E. Udo,
Mehrez M. Jadaon,
M. John Albert
Publication year - 2009
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01161-08
Subject(s) - ciprofloxacin , serotype , salmonella enterica , microbiology and biotechnology , salmonella typhi , biology , salmonella , enterobacteriaceae , quinolone , antibacterial agent , virology , gene , bacteria , genetics , antibiotics , escherichia coli
Blood isolates ofSalmonella enterica serovar Typhi from two recently returned Bangladeshi patients in Kuwait were ciprofloxacin resistant, with ciprofloxacin MICs of 12 mg/liter for both isolates. Both isolates had three novelgyrA mutations (55-Leu→Trp, 87-Asp→Ala, and 106-Gln→Arg) and three novelparC mutations (84-Glu→Lys, 106-Trp→Gly, and 128-Tyr→Asp).