Tuberculosis Outbreak in an Educational Institution in Norway | Zendy

Gunnstein Norheim | Zendy; Siri Seterelv | Zendy; Trude Arnesen | Zendy; Anne Torunn Mengshoel | Zendy; Tone Tønjum | Zendy; Janne O. Rønning | Zendy; Vegard Eldholm | Zendy

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Tuberculosis Outbreak in an Educational Institution in Norway

Author(s) -

Gunnstein Norheim,

Siri Seterelv,

Trude Arnesen,

Anne Torunn Mengshoel,

Tone Tønjum,

Janne O. Rønning,

Vegard Eldholm

Publication year - 2017

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01152-16

Subject(s) - tuberculosis , outbreak , medicine , virology , environmental health , pathology

Within 1 week in April 2013, three cases of pulmonary tuberculosis (TB) were reported among students attending training sessions at an educational institution in Oslo, Norway. By the end of October 2013, a total of nine epidemiologically linked cases had been reported. The outbreak encompassed a total of 24 cases from 2009 to 2014, among which all of the 22Mycobacterium tuberculosis isolates available had identical mycobacterial interspersed repetitive-unit–variable-number tandem-repeat (MIRU-VNTR) profiles (MtbC15-9 code 10287-189) belonging to the Beijing lineage. Whole-genome sequencing (WGS) of theM. tuberculosis isolates revealed 20 variable nucleotide positions within the cluster, indicating a clonal outbreak. The most likely index case was identified and diagnosed in Norway in 2009 but was born in Asia. WGS analyses verified that all of the cases were indeed part of a single transmission chain. However, even when combining WGS and intensified contact tracing, we were unable to fully reconstruct the TB transmission events.

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