Preanalytical Delay Reduces Sensitivity of QuantiFERON-TB Gold In-Tube Assay for Detection of Latent Tuberculosis Infection | Zendy

David Doberne | Zendy; Rajiv L. Gaur | Zendy; Niaz Banaei | Zendy

Open Access

Preanalytical Delay Reduces Sensitivity of QuantiFERON-TB Gold In-Tube Assay for Detection of Latent Tuberculosis Infection

Author(s) -

David Doberne,

Rajiv L. Gaur,

Niaz Banaei

Publication year - 2011

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01136-11

Subject(s) - reversion , medicine , gold standard (test) , tuberculosis , latent tuberculosis , quantiferon , incubation , mycobacterium tuberculosis , incubation period , immunology , gastroenterology , pathology , biology , phenotype , biochemistry , gene

The effects of incubation delays on the accuracy of the QuantiFERON-TB gold in-tube assay (QFT-GIT) were measured. Compared to immediate incubation, 6- and 12-hour delays resulted in positive-to-negative reversion rates of 19% (5/26) and 22% (5/23), respectively. These findings underscore the need for standardizing QFT-GIT preanalytical practices.

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