Open AccessThe Molecular Bacterial Load Assay Replaces Solid Culture for Measuring Early Bactericidal Response to Antituberculosis Treatment
Author(s) -
Isobella Honeyborne,
Bariki Mtafya,
Patrick Phillips,
Michael Höelscher,
Elias N. Ntinginya,
Anke Kohlenberg,
Andrea Rachow,
Gabriel Rojas-Ponce,
Timothy D. McHugh,
Norbert Heinrich
Publication year - 2014
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01128-14
Subject(s) - mycobacterium tuberculosis , microbiology and biotechnology , sputum , agar , liquid culture , tuberculosis , microbiological culture , mycobacterium , bacteria , sputum culture , biology , agar plate , liquid medium , chemistry , medicine , chromatography , pathology , genetics , botany
We evaluated the use of the molecular bacterial load (MBL) assay, for measuring viable Mycobacterium tuberculosis in sputum, in comparison with solid agar and liquid culture. The MBL assay provides early information on the rate of decline in bacterial load and has technical advantages over culture in either form.
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