Recognition of Potentially Novel Human Disease-Associated Pathogens by Implementation of Systematic 16S rRNA Gene Sequencing in the Diagnostic Laboratory | Zendy

Peter M. Keller | Zendy; Silvana K. Rampini | Zendy; Andrea Büchler | Zendy; Gerhard Eich | Zendy; Roger M. Wanner | Zendy; Roberto F. Speck | Zendy; Erik C. Böttger | Zendy; Guido V. Bloemberg | Zendy

Open Access

Recognition of Potentially Novel Human Disease-Associated Pathogens by Implementation of Systematic 16S rRNA Gene Sequencing in the Diagnostic Laboratory

Author(s) -

Peter M. Keller,

Silvana K. Rampini,

Andrea Büchler,

Gerhard Eich,

Roger M. Wanner,

Roberto F. Speck,

Erik C. Böttger,

Guido V. Bloemberg

Publication year - 2010

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01098-10

Subject(s) - biology , computational biology , 16s ribosomal rna , molecular diagnostics , human disease , metagenomics , dna sequencing , ribosomal rna , gene , microbiology and biotechnology , genetics

Clinical isolates that are difficult to identify by conventional means form a valuable source of novel human pathogens. We report on a 5-year study based on systematic 16S rRNA gene sequence analysis. We found 60 previously unknown 16S rRNA sequences corresponding to potentially novel bacterial taxa. For 30 of 60 isolates, clinical relevance was evaluated; 18 of the 30 isolates analyzed were considered to be associated with human disease.

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