Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen | Zendy

Linh Thuy Nguyen | Zendy; Linda Dunford | Zendy; Ines Freitas | Zendy; Paul Holder | Zendy; Lan Nguyen | Zendy; Joanne O’Gorman | Zendy; Jeff Connell | Zendy; Michael J. Carr | Zendy; William W. Hall | Zendy; Cillian De Gascun | Zendy

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Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen

Author(s) -

Linh Thuy Nguyen,

Linda Dunford,

Ines Freitas,

Paul Holder,

Lan Nguyen,

Joanne O’Gorman,

Jeff Connell,

Michael J. Carr,

William W. Hall,

Cillian De Gascun

Publication year - 2015

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01062-15

Subject(s) - virology , genotype , hepatitis c virus , serology , biology , antigen , virus , hepacivirus , flaviviridae , rna , immunology , antibody , gene , genetics

Genetic characterization of the genotype 3a (GT3a) hepatitis C virus (HCV) core region from HCV core antigen (HCVcAg)-negative/RNA-positive cases and HCVcAg-positive/RNA-positive controls identified significant associations between the substitutions A48T and T49A/P and failure to detect HCVcAg (P < 0.05). Polymorphisms at residues 48 and 49 in the core protein are present across all major epidemic and endemic GTs. These findings have implications for HCV diagnosis, particularly in low-income regions in which GT3a HCV is endemic.

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