Implication of Broadly Neutralizing Bovine Monoclonal Antibodies in the Development of an Enzyme-Linked Immunosorbent Assay for Detecting Neutralizing Antibodies against Foot-and-Mouth Disease Virus Serotype O | Zendy

Yimei Cao | Zendy; Kun Li | Zendy; Sheng Wang | Zendy; Yuanfang Fu | Zendy; Pu Sun | Zendy; Pinghua Li | Zendy; Xingwen Bai | Zendy; Jing Zhang | Zendy; Xueqing Ma | Zendy; Xiangchuan Xing | Zendy; Shasha Zhou | Zendy; Huifang Bao | Zendy; Dong Li | Zendy; Yingli Chen | Zendy; Zhiyong Li | Zendy; Zengjun Lu | Zendy; Zaixin Liu | Zendy

Open Access

Implication of Broadly Neutralizing Bovine Monoclonal Antibodies in the Development of an Enzyme-Linked Immunosorbent Assay for Detecting Neutralizing Antibodies against Foot-and-Mouth Disease Virus Serotype O

Author(s) -

Yimei Cao,

Kun Li,

Sheng Wang,

Yuanfang Fu,

Pu Sun,

Pinghua Li,

Xingwen Bai,

Jing Zhang,

Xueqing Ma,

Xiangchuan Xing,

Shasha Zhou,

Huifang Bao,

Dong Li,

Yingli Chen,

Zhiyong Li,

Zengjun Lu,

Zaixin Liu

Publication year - 2019

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01030-19

Subject(s) - virology , antibody , foot and mouth disease virus , serotype , neutralizing antibody , virus , neutralization , monoclonal antibody , titer , biology , foot and mouth disease , vaccination , immunology

Vaccination with inactivated vaccines is still the main measure to control foot-and-mouth disease (FMD) in areas where the disease is endemic, and the level of neutralizing antibody in vaccinated animals is directly related to their protection against virus challenge. Currently, neutralizing antibody is mainly detected using the virus neutralization test (VNT) based on cell culture, which is laborious and time-consuming and requires restrictive biocontainment facilities.

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