Open AccessSingle-Nucleotide Polymorphism in the fadD28 Gene as a Genetic Marker for East Asia Lineage Mycobacterium tuberculosis
Author(s) -
PeiChun Chuang,
Huang-Yau Chen,
Ruwen Jou
Publication year - 2010
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00970-10
Subject(s) - mycobacterium tuberculosis , lineage (genetic) , biology , genotype , genetics , tuberculosis , single nucleotide polymorphism , gene , genetic marker , virology , medicine , pathology
Mycobacterium tuberculosis isolates with a region of difference 105 (RD105) deletion, mainly Beijing family spoligotypes, were phylogenetically grouped into the East Asia lineage. We identified a single nucleotide polymorphism in codon 507, ATC to ATT, of the fadD28 gene as a robust marker and developed a rapid assay for East Asia lineage M. tuberculosis.
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