Open AccessCatheter-Related Bacteremia Caused by Multidrug-Resistant Leclercia adecarboxylata in a Patient with Breast Cancer
Author(s) -
GeeWook Shin,
Myung-Jo You,
Hye Soo Lee,
ChangSeop Lee
Publication year - 2012
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00948-12
Subject(s) - bacteremia , microbiology and biotechnology , antibiotics , catheter , multiple drug resistance , strain (injury) , breast cancer , biology , drug resistance , medicine , cancer , surgery
We report a multidrug-resistant strain of Leclercia adecarboxylata responsible for catheter-related bacteremia in a 47-year-old female with breast cancer. The isolated strain was resistant to several β-lactams, aminoglycosides, and folate pathway inhibitors and harbored bla(TEM-1) and bla(CTX-M) group 1 and intl1 genes (dfrA12-orfF-aadA2) as genetic determinants for resistance. Based on a review of the L. adecarboxylata literature, there have been only 4 reports of antibiotic-resistant strains. To our knowledge, this is the first report of an L. adecarboxylata strain with simultaneous resistance to β-lactams, aminoglycosides, and sulfonamides.
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