Open AccessFirst Detection of the Ambler Class C 1 AmpC β-Lactamase in Citrobacter freundii by a New, Simple Double-Disk Synergy Test
Author(s) -
Étienne Ruppé,
Philippe Bidet,
Charlotte Verdet,
Guillaume Arlet,
Édouard Bingen
Publication year - 2006
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00918-06
Subject(s) - citrobacter freundii , cefoxitin , cloxacillin , klebsiella pneumoniae , enterobacteriaceae , microbiology and biotechnology , biology , citrobacter , beta lactamase , enterobacter , escherichia coli , staphylococcus aureus , bacteria , antibiotics , genetics , penicillin , gene
We report on the first detection of an AmpC-type Ambler class C 1 (ACC-1) β-lactamase inCitrobacter freundi isolated from a patient also harboring ACC-1-producingEscherichia coli andKlebsiella pneumoniae . We propose a simple cefoxitin-based double-disk synergy test (DDST) for the specific detection of ACC-1 in members of the familyEnterobacteriaceae , including natural AmpC producers, in association with a cloxacillin-based DDST as a first-line AmpC-type β-lactamase screening test.