Molecular Characterization of a Catalase-Negative Staphylococcus aureus subsp. aureus Strain Collected from a Patient with Mitral Valve Endocarditis and Pericarditis Revealed a Novel Nonsense Mutation in the katA Gene | Zendy

Kelvin KaiWang To | Zendy; Vincent ChiChung Cheng | Zendy; Jasper FukWoo Chan | Zendy; Amy C. Y. Wong | Zendy; Sandy Ka-Yee Chau | Zendy; Flora Hau Fung Tsang | Zendy; Shirly O. T. Curreem | Zendy; Susanna K. P. Lau | Zendy; KwokYung Yuen | Zendy; Patrick C. Y. Woo | Zendy

Open Access

Molecular Characterization of a Catalase-Negative Staphylococcus aureus subsp. aureus Strain Collected from a Patient with Mitral Valve Endocarditis and Pericarditis Revealed a Novel Nonsense Mutation in the katA Gene

Author(s) -

Kelvin KaiWang To,

Vincent ChiChung Cheng,

Jasper FukWoo Chan,

Amy C. Y. Wong,

Sandy Ka-Yee Chau,

Flora Hau Fung Tsang,

Shirly O. T. Curreem,

Susanna K. P. Lau,

KwokYung Yuen,

Patrick C. Y. Woo

Publication year - 2011

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00849-11

Subject(s) - staphylococcus aureus , microbiology and biotechnology , endocarditis , infective endocarditis , strain (injury) , biology , micrococcaceae , pericarditis , staphylococcal infections , medicine , bacteria , genetics , cardiology , anatomy

We report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis.

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