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Colorex Strep A agar (CHROMagar, Paris, France) was evaluated with PhenoMATRIX chromogenic detection module (CDM) software (Copan Diagnostics Inc., Murrieta, CA) to detect group A Streptococcus (GAS) from throat specimens. The software results were compared to those of manual plate image reading. In addition, GAS PCR testing was performed on all specimens. True-positive specimens were defined as culture-positive (by either PhenoMATRIX CDM or manual reading) specimens confirmed as GAS by matrix-assisted laser desorption ionization-time of flight mass spectrometry plus any culture-negative specimens that were positive by both initial and repeat PCR testing. Of 480 specimens, 96 were considered true-positive specimens. Software reading of the chromogenic agar for suspected colonies detected 110 orange colonies, whereas technologist reading interpreted only 93/110 specimens (84.5%) as positive. None of the 361 cultures interpreted as negative by the PhenoMATRIX CDM software was positive by manual reading. In comparison with true-positive results, the sensitivity and specificity were 96.9% and 100% for PCR testing, 87.5% and 97.7% for technologist reading of chromogenic agar, 90.6% and 94.0% for software reading of chromogenic agar, 83.3% and 97.7% for technologist reading for β-hemolysis on blood agar, and 39.5% and 83.1% for technologist reading for β-hemolysis on blood agar accompanied by any zone of inhibition around a bacitracin-impregnated disk, respectively. The software had the most accurate results of the non-molecular testing methods, detecting all suspected colonies on the chromogenic agar and identifying 3 additional true-positive specimens that were missed by manual reading. The PhenoMATRIX CDM software and the Colorex Strep A agar can improve detection of GAS from throat specimens, and they compared favorably to molecular testing.

journal of clinical microbiology

Automated Detection of Streptococcus pyogenes Pharyngitis by Use of Colorex Strep A CHROMagar and WASPLab Artificial Intelligence Chromogenic Detection Module Software