Streptococcus sanguinis Isolate Displaying a Phenotype with Cross-Resistance to Several rRNA-Targeting Agents | Zendy

Rodrigo E. Mendes | Zendy; Lalitagauri M. Deshpande | Zendy; Jihye Kim | Zendy; Debra S. Myers | Zendy; James E. Ross | Zendy; Ronald N. Jones | Zendy

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Streptococcus sanguinis Isolate Displaying a Phenotype with Cross-Resistance to Several rRNA-Targeting Agents

Author(s) -

Rodrigo E. Mendes,

Lalitagauri M. Deshpande,

Jihye Kim,

Debra S. Myers,

James E. Ross,

Ronald N. Jones

Publication year - 2013

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00757-13

Subject(s) - streptococcus sanguinis , linezolid , staphylococcus epidermidis , microbiology and biotechnology , 23s ribosomal rna , endocarditis , staphylococcus aureus , ribosomal rna , antimicrobial , biology , streptococcus mutans , medicine , bacteria , ribosome , genetics , vancomycin , gene , rna

This study describes a clinical case of a 71-year-old male with a history of ischemic cardiomyopathy after left ventricular assist device (LVAD) endocarditis caused by methicillin-resistant Staphylococcus epidermidis (MRSE) and a rare linezolid-resistant Streptococcus sanguinis strain (MIC, 32 μg/ml). The patient received courses of several antimicrobial agents, including linezolid for 79 days. The S. sanguinis strain had mutations in the 23S rRNA (T2211C, T2406C, G2576T, C2610T) and an amino acid substitution (N56D) in L22 and exhibited cross-resistance to ribosome-targeting agents.

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