Impact of Laboratory Cross-Contamination on Molecular Epidemiology Studies of Tuberculosis | Zendy

Miguel MartínezLirola | Zendy; Darı́o Garcı́a de Viedma | Zendy; María Alonso | Zendy; Sandra Andrés | Zendy; Emilio Bouza | Zendy; Teresa Cabezas | Zendy; Isabel Cabeza | Zendy; A. Reyes | Zendy; Waldo Sánchez-Yebra | Zendy; Manuel Rodríguez | Zendy; M. Isabel Sánchez | Zendy; M. Cruz Rogado | Zendy; Rosa Fernández Fernández | Zendy; Teresa Peñafiel | Zendy; Juan Martínez | Zendy; Pilar Barroso | Zendy; M. Ángeles Lucerna | Zendy; Díez García F | Zendy; Carmelo Gutiérrez | Zendy

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Impact of Laboratory Cross-Contamination on Molecular Epidemiology Studies of Tuberculosis

Author(s) -

Miguel MartínezLirola,

Darı́o Garcı́a de Viedma,

María Alonso,

Sandra Andrés,

Emilio Bouza,

Teresa Cabezas,

Isabel Cabeza,

A. Reyes,

Waldo Sánchez-Yebra,

Manuel Rodríguez,

M. Isabel Sánchez,

M. Cruz Rogado,

Rosa Fernández Fernández,

Teresa Peñafiel,

Juan Martínez,

Pilar Barroso,

M. Ángeles Lucerna,

Díez García F,

Carmelo Gutiérrez

Publication year - 2006

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00754-06

Subject(s) - tuberculosis , mycobacterium tuberculosis , molecular epidemiology , contamination , genotyping , epidemiology , transmission (telecommunications) , biology , microbiology and biotechnology , medicine , genotype , genetics , pathology , ecology , gene , electrical engineering , engineering

Laboratory cross-contamination by Mycobacterium tuberculosis is known to be responsible for the misdiagnosis of tuberculosis, but its impact on other contexts has not been analyzed. We present the findings of a molecular epidemiology analysis in which the recent transmission events identified by a genotyping reference center were overestimated as a result of unnoticed laboratory cross-contamination in the original diagnostic laboratories.

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