Open AccessGenetic Heterogeneity in Clinical Isolates of Leishmania donovani from India
Author(s) -
Pankaj Srivastava,
T. N. Singh,
Shyam Sundar
Publication year - 2011
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00729-11
Subject(s) - leishmania donovani , biology , microbiology and biotechnology , leishmaniasis , leishmania , protozoal disease , virology , genetics , visceral leishmaniasis , immunology , malaria , parasite hosting , world wide web , computer science
Genetic diversity within 45 IndianLeishmania donovani isolates was analyzed using seven genetic markers. While kinetoplast DNA (kDNA) analysis revealed 15 genotypes, 8 genotypes were obtained by analysis of other markers. In contrast to earlier reports, our data suggest that significant genetic polymorphisms exist inL. donovani strains in Bihar, India. Our results confirm the presence of 2 zymodemes in India.