Changes in MMP-9 and TIMP-1 Concentrations in Cerebrospinal Fluid after 1 Week of Treatment of Childhood Bacterial Meningitis | Zendy

Irmeli Roine | Zendy; Tuula Pelkonen | Zendy; Anneli Lauhio | Zendy; Maija Lappalainen | Zendy; Manuel Leite Cruzeiro | Zendy; Luís Bernardino | Zendy; Taina Tervahartiala | Zendy; Timo Sorsa | Zendy; Heikki Peltola | Zendy

Open Access

Changes in MMP-9 and TIMP-1 Concentrations in Cerebrospinal Fluid after 1 Week of Treatment of Childhood Bacterial Meningitis

Author(s) -

Irmeli Roine,

Tuula Pelkonen,

Anneli Lauhio,

Maija Lappalainen,

Manuel Leite Cruzeiro,

Luís Bernardino,

Taina Tervahartiala,

Timo Sorsa,

Heikki Peltola

Publication year - 2015

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00714-15

Subject(s) - cerebrospinal fluid , bacterial meningitis , meningitis , matrix metalloproteinase , medicine , bacteria , pathology , microbiology and biotechnology , immunology , biology , surgery , genetics

We explored the changes of the initially highly upgraded cerebrospinal fluid matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of MMP 1 (TIMP-1) response during recovery of childhood bacterial meningitis and their association with outcome. The sizes of these changes varied substantially, but a steeper decrease in the MMP-9 and an increase of the TIMP-1 concentrations augured a better outcome.

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