Open AccessParvovirus B19 Infection Localized in the Intestinal Mucosa and Associated with Severe Inflammatory Bowel Disease
Author(s) -
Loris Pironi,
Francesca Bonvicini,
Paolo Gionchetti,
Antonietta D’Errico,
Fernando Rizzello,
Catia Corsini,
Laura Foroni,
Giorgio Gallinella
Publication year - 2009
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00706-08
Subject(s) - parvovirus , inflammatory bowel disease , intestinal mucosa , parvoviridae , medicine , disease , immunology , pathology , virology , microbiology and biotechnology , biology , virus
Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bowel disease, characterized by duodenal villous atrophy with increased intraepithelial lymphocytes and inflammatory infiltrates in the colonic mucosa. Virus in the intestinal mucosa was detected in cells of the inflammatory infiltrate, identified as T lymphocytes and selectively localized in sites of active tissue degeneration.