Recovery of Influenza B Virus with the H273Y Point Mutation in the Neuraminidase Active Site from a Human Patient | Zendy

Rachel R. Higgins | Zendy; Melissa Beniprashad | Zendy; Eddie Chong-King | Zendy; Yan Li | Zendy; Nathalie Bastien | Zendy; Donald E. Low | Zendy; Jonathan B. Gubbay | Zendy

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Recovery of Influenza B Virus with the H273Y Point Mutation in the Neuraminidase Active Site from a Human Patient

Author(s) -

Rachel R. Higgins,

Melissa Beniprashad,

Eddie Chong-King,

Yan Li,

Nathalie Bastien,

Donald E. Low,

Jonathan B. Gubbay

Publication year - 2012

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00682-12

Subject(s) - oseltamivir , zanamivir , neuraminidase , virology , neuraminidase inhibitor , human influenza , point mutation , mutation , influenza a virus , influenzavirus b , virus , microbiology and biotechnology , resistance mutation , drug resistance , biology , orthomyxoviridae , medicine , covid-19 , gene , genetics , polymerase chain reaction , infectious disease (medical specialty) , disease , reverse transcriptase , pathology

The H275Y oseltamivir resistance mutation confers high-level resistance to oseltamivir in isolates of human A(H1N1) influenza. We report the recovery and identification of an influenza B virus with the H273Y neuraminidase point mutation directly from a human patient. The H273Y influenza B isolate is resistant to oseltamivir and peramivir but sensitive to zanamivir.

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