Open AccessPerformance of Human Immunodeficiency Virus Type 1 gp41 Assays for Detecting Enfuvirtide (T-20) Resistance Mutations
Author(s) -
Michelle Marcial,
Jing Lü,
Steven G. Deeks,
Rainer Ziermann,
Daniel R. Kuritzkes
Publication year - 2006
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00666-06
Subject(s) - enfuvirtide , gp41 , virology , biology , human immunodeficiency virus (hiv) , lentivirus , sequence (biology) , mutation , dna sequencing , virus , viral disease , immunology , dna , genetics , antibody , gene , epitope
The performance of a gp41 assay, created using reagents designed for use with the OpenGene DNA Sequencing System, was evaluated using a panel of plasma samples obtained from enfuvirtide-naive and -experienced human immunodeficiency virus type 1-infected subjects. Resulting sequence data were highly accurate compared to a “home brew” assay and clonal sequence analysis.