Prospective Cohort Study on Performance of Cerebrospinal Fluid (CSF) Xpert MTB/RIF, CSF Lipoarabinomannan (LAM) Lateral Flow Assay (LFA), and Urine LAM LFA for Diagnosis of Tuberculous Meningitis in Zambia | Zendy

Omar K. Siddiqi | Zendy; Gretchen L. Birbeck | Zendy; Musie Ghebremichael | Zendy; Eugene Mubanga | Zendy; Shawn Love | Zendy; Clayton Buback | Zendy; Barry Kosloff | Zendy; Helen Ayles | Zendy; Masharip Atadzhanov | Zendy; Keertan Dheda | Zendy; Igor J. Koralnik | Zendy

Open Access

Prospective Cohort Study on Performance of Cerebrospinal Fluid (CSF) Xpert MTB/RIF, CSF Lipoarabinomannan (LAM) Lateral Flow Assay (LFA), and Urine LAM LFA for Diagnosis of Tuberculous Meningitis in Zambia

Author(s) -

Omar K. Siddiqi,

Gretchen L. Birbeck,

Musie Ghebremichael,

Eugene Mubanga,

Shawn Love,

Clayton Buback,

Barry Kosloff,

Helen Ayles,

Masharip Atadzhanov,

Keertan Dheda,

Igor J. Koralnik

Publication year - 2019

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00652-19

Subject(s) - lipoarabinomannan , cerebrospinal fluid , tuberculous meningitis , medicine , meningitis , virology , urine , immunology , tuberculosis , pathology , mycobacterium tuberculosis , surgery

Tuberculous meningitis (TBM) is a devastating infection of the central nervous system lacking an adequate point-of-care diagnostic test. We conducted a prospective cohort study of 550 Zambian adults with suspected TBM to determine the diagnostic accuracy of cerebrospinal fluid (CSF) Xpert MTB/RIF, CSF lipoarabinomannan (LAM), urine LAM, CSF total protein, and CSF glucose compared with the gold standard of CSF culture.

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