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Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Testing Susceptible to Cefepime by Reference Methods
Author(s) -
Renata Cristina Picão,
Ronald N. Jones,
Rodrigo E. Mendes,
Mariana Castanheira
Publication year - 2013
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00640-13
Subject(s) - cefepime , meropenem , klebsiella pneumoniae , broth microdilution , enterobacteriaceae , microbiology and biotechnology , ceftazidime , biology , cephalosporin , medicine , antibiotics , bacteria , imipenem , minimum inhibitory concentration , antibiotic resistance , escherichia coli , pseudomonas aeruginosa , biochemistry , genetics , gene
β-Lactam susceptibility of 499 Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae, determined by reference broth microdilution, demonstrated that 14.4% of isolates were categorized as cefepime susceptible according to current CLSI breakpoints. Ceftazidime- and meropenem-susceptible isolates were also observed (2.6 and 3.0%, respectively). Cefepime-susceptible KPC-producing isolates may confuse laboratory staff and clinicians in their therapeutic choices.

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