Comparison of Dalbavancin MIC Values Determined by Etest (AB BIODISK) and Reference Dilution Methods Using Gram-Positive Organisms | Zendy

Thomas R. Fritsche | Zendy; Robert Rennie | Zendy; Beth P. Goldstein | Zendy; Ronald N. Jones | Zendy

Open Access

Comparison of Dalbavancin MIC Values Determined by Etest (AB BIODISK) and Reference Dilution Methods Using Gram-Positive Organisms

Author(s) -

Thomas R. Fritsche,

Robert Rennie,

Beth P. Goldstein,

Ronald N. Jones

Publication year - 2006

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00640-06

Subject(s) - etest , dalbavancin , broth microdilution , microbiology and biotechnology , minimum inhibitory concentration , biology , antimicrobial , bacteria , vancomycin , genetics , staphylococcus aureus

While standardized microdilution testing methodologies and quality control ranges exist for the novel glycolipopeptide dalbavancin, no testing methods have been described that are immediately available for routine use in clinical laboratories. In this study, we found that the dalbavancin Etest (AB BIODISK, Solna, Sweden) procedure demonstrated a high degree of agreement (100% within +/-2 log(2) dilution steps) with the standardized broth microdilution method, validating the use of the Etest as an alternative test for investigational or clinical purposes following regulatory approval.

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