Simultaneous Identification of Multiple β-Lactamases in Acinetobacter baumannii in Relation to Carbapenem and Ceftazidime Resistance, Using Liquid Chromatography-Tandem Mass Spectrometry | Zendy

Hein Trip | Zendy; Katrin Mende | Zendy; J.A. Majchrzykiewicz-Koehorst | Zendy; Norbert J.A. Sedee | Zendy; Albert G. Hulst | Zendy; Hugo-Jan Jansen | Zendy; Clinton K. Murray | Zendy; Armand Paauw | Zendy

Open Access

Simultaneous Identification of Multiple β-Lactamases in Acinetobacter baumannii in Relation to Carbapenem and Ceftazidime Resistance, Using Liquid Chromatography-Tandem Mass Spectrometry

Author(s) -

Hein Trip,

Katrin Mende,

J.A. Majchrzykiewicz-Koehorst,

Norbert J.A. Sedee,

Albert G. Hulst,

Hugo-Jan Jansen,

Clinton K. Murray,

Armand Paauw

Publication year - 2015

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00620-15

Subject(s) - acinetobacter baumannii , ceftazidime , acinetobacter , chromatography , microbiology and biotechnology , carbapenem , tandem mass spectrometry , liquid chromatography–mass spectrometry , mass spectrometry , medicine , biology , chemistry , antibiotics , bacteria , genetics , pseudomonas aeruginosa

Shotgun proteomics using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was applied to detect β-lactamases in clinical Acinetobacter baumannii isolates. The correlation of the detection of β-lactamase proteins (rather than PCR detection of the corresponding genes) with the resistance phenotypes demonstrated an added value for LC-MS/MS in antimicrobial susceptibility testing.

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