Open AccessDevelopment of Oxacillin Resistance in a Patient with Recurrent Staphylococcus aureus Bacteremia
Author(s) -
Eileen M. Burd,
Mohammad Tauqeer Alam,
Karla D. Passalacqua,
Ameeta S. Kalokhe,
Molly E. Eaton,
Sarah W. Satola,
Colleen S. Kraft,
Timothy D. Read
Publication year - 2014
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00615-14
Subject(s) - staphylococcus aureus , microbiology and biotechnology , sccmec , teichoic acid , micrococcaceae , bacteremia , frameshift mutation , gene , biology , staphylococcal infections , staphylococcus , methicillin resistant staphylococcus aureus , bacteria , genetics , exon , antibiotics
Whole-genome sequencing was used to compare longitudinal isolates of Staphylococcus aureus that developed resistance to oxacillin (MIC up to 16 μg/ml). The mecA gene was absent. A novel 5-bp TATCC frameshift insertion in a gene encoding an ABC transporter similar to that of the teichoic acid translocation ATP-binding protein TagH and a 3-bp GCT nonframeshift insertion in the pdhA pyruvate dehydrogenase gene were detected in the oxacillin-resistant isolates.
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