A Novel Broad Allele-Specific TaqMan Real-Time PCR Method To Detect Triazole-Resistant Strains of Aspergillus fumigatus, Even with a Very Low Percentage of Triazole-Resistant Cells Mixed with Triazole-Susceptible Cells | Zendy

Qian Wang | Zendy; Dimitrios P. Kontoyiannis | Zendy; Ruoyu Li | Zendy; Wei Chen | Zendy; Dingfang Bu | Zendy; Wei Liu | Zendy

Open Access

A Novel Broad Allele-Specific TaqMan Real-Time PCR Method To Detect Triazole-Resistant Strains of Aspergillus fumigatus, Even with a Very Low Percentage of Triazole-Resistant Cells Mixed with Triazole-Susceptible Cells

Author(s) -

Qian Wang,

Dimitrios P. Kontoyiannis,

Ruoyu Li,

Wei Chen,

Dingfang Bu,

Wei Liu

Publication year - 2019

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00604-19

Subject(s) - aspergillus fumigatus , taqman , microbiology and biotechnology , biology , triazole , aspergillosis , polymerase chain reaction , drug resistance , virology , gene , chemistry , genetics , immunology , organic chemistry

Invasive aspergillosis caused by triazole-resistant strains ofAspergillus fumigatus is a growing public health concern, as is the occurrence of mixed infections with triazole-resistant and -susceptibleA. fumigatus strains. Therefore, it is crucial to develop robust methods to identify triazole-resistant strains ofA. fumigatus , even in mixtures of triazole-resistant and -susceptible strains ofA. fumigatus .

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