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Data on the epidemiology of invasive candidiasis (IC) and the antifungal susceptibility ofCandida isolates in China are still limited. Here we report on surveillance for IC from the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) study. Sixty-five tertiary hospitals collected 8,829Candida isolates from 1 August 2009 to 31 July 2014. Matrix-assisted laser desorption ionization–time of flight mass spectrometry supplemented by ribosomal DNA sequencing was used to define the species, and the fluconazole and voriconazole susceptibilities were determined by the Clinical and Laboratory Standards Institute disk diffusion method. A total of 32Candida species were identified.Candida albicans was the most common species (44.9%), followed by theC. parapsilosis complex (20.0%),C. tropicalis (17.2%), and theC. glabrata complex (10.8%), with other species comprising &lt;3% of isolates. However, in candidemia, the proportion of cases caused byC. albicans was only 32.3%.C. albicans andC. parapsilosis complex isolates were susceptible to fluconazole and voriconazole (&lt;6% resistance), while fluconazole and azole cross-resistance rates were high inC. tropicalis (13.3% and 12.9%, respectively),C. glabrata complex (18.7% and 14%, respectively), and uncommonCandida species (44.1% and 10.3%, respectively) isolates. Moreover, from years 1 to 5 of the study, there was a significant increase in the rates of resistance to fluconazole amongC. glabrata complex isolates (12.2% to 24.0%) and to both fluconazole (5.7% to 21.0%) and voriconazole (5.7% to 21.4%) amongC. tropicalis isolates (P &lt; 0.01 for all comparisons). Geographic variations in the causative species and susceptibilities were noted. Our findings indicate that antifungal resistance has become noteworthy in China, and enhanced surveillance is warranted.

journal of clinical microbiology

Five-Year National Surveillance of Invasive Candidiasis: Species Distribution and Azole Susceptibility from the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study