Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in São Paulo, Brazil | Zendy

Nathalia Mantovani | Zendy; R Gonçalves Azevedo | Zendy; J. T. Rabelato | Zendy; Sabri Saeed Sanabani | Zendy; Ricardo Sobhie Diaz | Zendy; Shirley Vasconcelos Komninakis | Zendy

Open Access

Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in São Paulo, Brazil

Author(s) -

Nathalia Mantovani,

R Gonçalves Azevedo,

J. T. Rabelato,

Sabri Saeed Sanabani,

Ricardo Sobhie Diaz,

Shirley Vasconcelos Komninakis

Publication year - 2012

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00539-12

Subject(s) - raltegravir , integrase , integrase inhibitor , virology , human immunodeficiency virus (hiv) , drug resistance , biology , lentivirus , hiv drug resistance , medicine , genetics , viral disease , viral load , antiretroviral therapy

We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance.

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