Emergence of G186D Mutation in the Presence of R292K Mutation in an Immunocompromised Child Infected with Influenza A/H3N2 Virus, Treated with Oseltamivir | Zendy

Hong Kai Lee | Zendy; Julian W. Tang | Zendy; Tze Ping Loh | Zendy; Debra Han-Lin Kong | Zendy; Yew-Weng Lau | Zendy; HuiKim Yap | Zendy; Evelyn Siew-Chuan Koay | Zendy

Open Access

Emergence of G186D Mutation in the Presence of R292K Mutation in an Immunocompromised Child Infected with Influenza A/H3N2 Virus, Treated with Oseltamivir

Author(s) -

Hong Kai Lee,

Julian W. Tang,

Tze Ping Loh,

Debra Han-Lin Kong,

Yew-Weng Lau,

HuiKim Yap,

Evelyn Siew-Chuan Koay

Publication year - 2014

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00538-14

Subject(s) - oseltamivir , virology , mutation , virus , biology , influenza a virus , orthomyxoviridae , medicine , genetics , covid-19 , gene , disease , pathology , infectious disease (medical specialty)

An immunocompromised child with influenza A/H3N2 virus infection, treated with oseltamivir from day 1, had nasal swabs taken on days 1, 4, 7, and 10 of the illness. Pyrosequencing showed increasing proportions of viruses with R292K (neuraminidase gene) and G186D (hemagglutinin gene) mutations, resulting in a viral load rebound by day 10.

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