A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests | Zendy

Caoimhe Nic Fhogartaigh | Zendy; David A. B. Dance | Zendy; Viengmon Davong | Zendy; Pisey Tann | Zendy; Rattanaphone Phetsouvanh | Zendy; Paul Turner | Zendy; Sabine Dittrich | Zendy; Paul N. Newton | Zendy

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A Novel Technique for Detecting Antibiotic-Resistant Typhoid from Rapid Diagnostic Tests

Author(s) -

Caoimhe Nic Fhogartaigh,

David A. B. Dance,

Viengmon Davong,

Pisey Tann,

Rattanaphone Phetsouvanh,

Paul Turner,

Sabine Dittrich,

Paul N. Newton

Publication year - 2015

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00531-15

Subject(s) - typhoid fever , salmonella typhi , diagnostic test , antibiotics , virology , molecular diagnostics , medicine , microbiology and biotechnology , biology , immunology , genetics , veterinary medicine , gene , escherichia coli

Fluoroquinolone-resistant typhoid is increasing. An antigen-detecting rapid diagnostic test (RDT) can rapidly diagnose typhoid from blood cultures. A simple, inexpensive molecular technique performed with DNA from positive RDTs accurately identified gyrA mutations consistent with phenotypic susceptibility testing results. Field diagnosis combined with centralized molecular resistance testing could improve typhoid management and surveillance in low-resource settings.

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