Azole Resistance of Candida glabrata in a Case of Recurrent Fungemia | Zendy

Brunella Posteraro | Zendy; Mario Tumbarello | Zendy; Marilena La Sorda | Zendy; Teresa Spanu | Zendy; Enrico Maria Trecarichi | Zendy; Flavia De Bernardis | Zendy; Giancarlo Scoppettuolo | Zendy; Maurizio Sanguinetti | Zendy; Giovanni Fadda | Zendy

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Azole Resistance of Candida glabrata in a Case of Recurrent Fungemia

Author(s) -

Brunella Posteraro,

Mario Tumbarello,

Marilena La Sorda,

Teresa Spanu,

Enrico Maria Trecarichi,

Flavia De Bernardis,

Giancarlo Scoppettuolo,

Maurizio Sanguinetti,

Giovanni Fadda

Publication year - 2006

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00526-06

Subject(s) - fungemia , candida glabrata , microbiology and biotechnology , azole , medicine , mycosis , fungi imperfecti , biology , antifungal , immunology

We describe a case of recurrent Candida glabrata fungemia that became unresponsive to fluconazole treatment. Posttreatment isolates from blood and vaginal cultures of the immunocompetent patient were azole resistant and exhibited upregulated expression of CgCDR1/CgCDR2 efflux pumps compared to the original isolates. Amphotericin B therapy eradicated the infection.

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