The Poisoned Well: Enhancing the Predictive Value of Antimicrobial Susceptibility Testing in the Era of Multidrug Resistance | Zendy

Thea Brennan-Krohn | Zendy; Kenny Smith | Zendy; James E. Kirby | Zendy

Open Access

The Poisoned Well: Enhancing the Predictive Value of Antimicrobial Susceptibility Testing in the Era of Multidrug Resistance

Author(s) -

Thea Brennan-Krohn,

Kenny Smith,

James E. Kirby

Publication year - 2017

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00511-17

Subject(s) - antimicrobial , multiple drug resistance , antibiotic resistance , predictive value , antibiotics , clinical microbiology , microbiology and biotechnology , medicine , biology

Antimicrobial susceptibility testing (AST) is a fundamental mission of the clinical microbiology laboratory. Reference AST methods are based on bacterial growth in antibiotic doubling dilution series, which means that any error in the reference method inherently represents at least a 2-fold difference. We describe the origins of current AST reference methodology, highlight the sources of AST variability, and propose ideas for improving AST predictive power.

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