Comparison of Broth Microdilution, Agar Dilution, and Etest for Susceptibility Testing of Doripenem against Gram-Negative and Gram-Positive Pathogens | Zendy

Karen Amsler | Zendy; Colleen M. Santoro | Zendy; Barbara D. Foleno | Zendy; Karen Bush | Zendy; Robert K. Flamm | Zendy

Open Access

Comparison of Broth Microdilution, Agar Dilution, and Etest for Susceptibility Testing of Doripenem against Gram-Negative and Gram-Positive Pathogens

Author(s) -

Karen Amsler,

Colleen M. Santoro,

Barbara D. Foleno,

Karen Bush,

Robert K. Flamm

Publication year - 2010

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00494-10

Subject(s) - etest , broth microdilution , agar dilution , doripenem , agar , microbiology and biotechnology , serial dilution , minimum inhibitory concentration , biology , gram , chromatography , chemistry , medicine , bacteria , antimicrobial , antibiotics , meropenem , antibiotic resistance , genetics , alternative medicine , pathology

The susceptibility of 513 clinical isolates to doripenem was determined by broth microdilution, agar dilution, and Etest. Overall agreements for Etest and agar dilution MIC values compared to reference broth microdilution at +/-1 log(2) dilution were 88% and 94%, respectively. Etest MIC values demonstrated 98% agreement within +/-2 log(2) dilutions compared to the reference broth microdilution method.

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