Evaluation of Two Novel Rapid rKE16 Antigen-Based Tests for Diagnosis of Visceral Leishmaniasis in India | Zendy

Manisha Vaish | Zendy; Smriti Sharma | Zendy; Jaya Chakravarty | Zendy; Shyam Sundar | Zendy

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Evaluation of Two Novel Rapid rKE16 Antigen-Based Tests for Diagnosis of Visceral Leishmaniasis in India

Author(s) -

Manisha Vaish,

Smriti Sharma,

Jaya Chakravarty,

Shyam Sundar

Publication year - 2012

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00475-12

Subject(s) - visceral leishmaniasis , leishmaniasis , antigen , immunology , medicine , diagnostic test , pathology , veterinary medicine

We compared the two formats of rKE16 antigen-based rapid tests, a flowthrough test (KEFT) and a lateral flow test (KELF), with the rK39 rapid test for the diagnosis of visceral leishmaniasis. Sensitivities with KEFT (99%, 198/200) and rK39 (99.5%, 199/200) were comparable and higher than that with KELF (95.5%, 191/200). In the control groups comprising subjects with diseases from areas of nonendemicity or endemicity and subjects with different diseases, the specificities were comparable for all three rapid tests, except that specificity was higher with KELF in the controls from areas of endemicity.

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