QuantiFERON-TB Gold Plus Is a More Sensitive Screening Tool than QuantiFERON-TB Gold In-Tube for Latent Tuberculosis Infection among Older Adults in Long-Term Care Facilities | Zendy

JungYien Chien | Zendy; Hsiu-Tzy Chiang | Zendy; MinChi Lu | Zendy; WenChien Ko | Zendy; ChongJen Yu | Zendy; YenHsu Chen | Zendy; PoRen Hsueh | Zendy

Open Access

QuantiFERON-TB Gold Plus Is a More Sensitive Screening Tool than QuantiFERON-TB Gold In-Tube for Latent Tuberculosis Infection among Older Adults in Long-Term Care Facilities

Author(s) -

JungYien Chien,

Hsiu-Tzy Chiang,

MinChi Lu,

WenChien Ko,

ChongJen Yu,

YenHsu Chen,

PoRen Hsueh

Publication year - 2018

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00427-18

Subject(s) - medicine , latent tuberculosis , gold standard (test) , quantiferon , tuberculosis , gastroenterology , predictive value , interferon γ , mycobacterium tuberculosis , interferon gamma , pathology , cytokine

We investigated the prevalence of latent tuberculosis infection (LTBI) among the residents in seven long-term care facilities (LTCFs) located in different regions of Taiwan and compared the performance of two interferon gamma release assays, i.e., QuantiFERON-TB Gold In-Tube (QFT-GIT) and QuantiFERON-TB Gold Plus (QFT-Plus) for screening LTBI. We also assessed the diagnostic performance against a composite reference standard (subjects with persistent-positive, transient-positive, and negative results from QFTs during reproducibility analysis were classified as definite, possible, and not LTBI, respectively).

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