Open AccessCombat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics
Author(s) -
Aaron Farmer,
Clinton K. Murray,
Ian R. Driscoll,
Brian L. Wickes,
Nathan P. Wiederhold,
Deanna A. Sutton,
Carmita Sanders,
Katrin Mende,
Brent A. Enniss,
James Feig,
Anuradha Ganesan,
Elizabeth Rini,
Todd J. Vento
Publication year - 2015
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00410-15
Subject(s) - pythium aphanidermatum , histopathology , pythium , biology , coinfection , polytrauma , pathology , microbiology and biotechnology , virology , medicine , botany , surgery , biological pest control , virus
We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence- and culture-confirmedPythium aphanidermatum wound infection. Antemortem histopathology suggested disseminatedPythium infection, including brain involvement; however, postmortem PCR revealedCunninghamella elegans ,Lichtheimia corymbifera , andSaksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.
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