Open AccessWhole-Genome Sequence Analysis of Multidrug-Resistant Campylobacter Isolates: a Focus on Aminoglycoside Resistance Determinants
Author(s) -
A. Fabre,
Mónica Oleastro,
Alexandra Nunes,
Andrea Santos,
Elodie Sifré,
Astrid Ducournau,
Lucie Bénejat,
Alice Buissonnière,
Pauline Floch,
Françis Mégraud,
Véronique Dubois,
Philippe Lehours
Publication year - 2018
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00390-18
Subject(s) - biology , spectinomycin , campylobacter , microbiology and biotechnology , aminoglycoside , antibiotic resistance , genetics , gentamicin , campylobacter coli , antibiotics , bacteria
A whole-genome sequencing (WGS) approach was conducted in order to identify the molecular determinants associated with antimicrobial resistance in 12 multidrug-resistantCampylobacter jejuni andCampylobacter coli isolates, with a focus on aminoglycoside resistance determinants. Two variants of a new aminoglycoside phosphotransferase gene [aph (2 ″)-Ii1 andaph (2 ″)-Ii2 ] putatively associated with gentamicin resistance were found.
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