Evaluation of the Fully Automated BD MAX Cdiff and Xpert C. difficile Assays for Direct Detection of Clostridium difficile in Stool Specimens | Zendy

Alexander H. Dalpke | Zendy; Marjeta Hofko | Zendy; Markus Zorn | Zendy; Stefan Zimmermann | Zendy

Open Access

Evaluation of the Fully Automated BD MAX Cdiff and Xpert C. difficile Assays for Direct Detection of Clostridium difficile in Stool Specimens

Author(s) -

Alexander H. Dalpke,

Marjeta Hofko,

Markus Zorn,

Stefan Zimmermann

Publication year - 2013

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.00344-13

Subject(s) - clostridium difficile , c difficile , microbiology and biotechnology , genexpert mtb/rif , chromogenic , medicine , chromatography , biology , chemistry , pathology , antibiotics , mycobacterium tuberculosis , tuberculosis

We evaluated the fully automated molecular BD MAX Cdiff assay (BD Diagnostics) and the XpertC. difficile test (Cepheid) for rapid detection ofClostridium difficile infection. Culture was done on chromogenic agar followed by matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry identification and toxin detection. Repeat testing was required for 1.8% and 6.0% of the BD MAX and Xpert tests, respectively. Sensitivities, specificities, positive predictive values (PPV), and negative predictive values (NPV) were 90.5%, 97.9%, 89.3%, and 98.1%, respectively, for BD MAX and 97.3%, 97.9%, 90.0%, and 99.5%, respectively, for Xpert.

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