Open AccessDevelopment of Echinocandin Resistance in Clavispora lusitaniae during Caspofungin Treatment
Author(s) -
Marie DesnosOllivier,
Olivier Moquet,
Taïeb Chouaki,
Anne-Marie Guérin,
Françoise Dromer
Publication year - 2011
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.00325-11
Subject(s) - echinocandin , caspofungin , echinocandins , biology , microbiology and biotechnology , antifungal , voriconazole , fluconazole
Clavispora lusitaniae is an opportunistic human pathogen responsible for 0.6 to 2% of candidemia. This species is intrinsically susceptible to echinocandins. Nevertheless, in this study, development of echinocandin resistance in C. lusitaniae isolates was observed during caspofungin treatment. This resistance resulted from missense mutation in the echinocandin target Fks1 gene.
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